Predictive value of angiogenic proteins in patients with metastatic melanoma treated with bevacizumab monotherapy
نویسندگان
چکیده
منابع مشابه
Clinical Efficacy and Safety of Bevacizumab Monotherapy in Patients with Metastatic Melanoma: Predictive Importance of Induced Early Hypertension
BACKGROUND VEGF driven angiogenesis plays a key role in cancer progression. We determined the clinical efficacy of bevacizumab monotherapy in patients with metastatic melanoma. METHODS AND FINDINGS Thirty-five patients with metastatic melanoma in progression were enrolled in this phase II, single arm clinical trial. Each patient received bevacizumab monotherapy 10 mg/kg q14 d until intolerabl...
متن کاملBevacizumab plus ipilimumab in patients with metastatic melanoma.
Ipilimumab improves survival in advanced melanoma and can induce immune-mediated tumor vasculopathy. Besides promoting angiogenesis, vascular endothelial growth factor (VEGF) suppresses dendritic cell maturation and modulates lymphocyte endothelial trafficking. This study investigated the combination of CTLA4 blockade with ipilimumab and VEGF inhibition with bevacizumab. Patients with metastati...
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ژورنال
عنوان ژورنال: The Journal of Pathology: Clinical Research
سال: 2018
ISSN: 2056-4538
DOI: 10.1002/cjp2.116